The reporter learned from the Chinese Academy of Sciences that the research group Li Ying of the Institute of Genetics and Developmental Biology recently discovered that the SLC35D3 gene, which is located on the side of the long arm D6S1009 of human chromosome 6, is the causative gene of human obesity and metabolic syndrome. Related research was published in the United States "Science Public Library Genetics." Previous studies have shown that the D6S1009 locus located on the long arm of human chromosome 6 is closely related to body mass index BMI. According to observations made by a group of mice with a defect in the SLC35D3 gene flanking the site, the group found that the mouse showed progressive obesity and metabolic syndrome from a 2-month-old age (comparable to adulthood in humans). feature. Further studies have found that defects in the protein encoded by this gene can lead to obstruction of the transport of dopamine type I receptor membranes in the striatum of the basal ganglia, impaired signaling pathways, resulting in decreased exercise and energy consumption, and thus lead to obesity. disease. In addition, the research team identified mutations in the SLC35D3 gene in two Chinese adults with metabolic syndrome through collaboration with clinical units such as Qingdao University Medical College, and found that the frequency of mutations in the obesity population exceeded 1,000. Five in five. These findings indicate that the SLC35D3 gene is a causative gene for human obesity and metabolic syndrome.
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